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Additionally, for anxiety disorders, the cited figures can provide the prescriber with an indication as to the frequency with which physician intervention (eg, increased surveillance, decreased dosage or discontinuation of drug therapy) may be necessary because of the untoward clinical event.
Studies supporting this claim were conducted in patients whose diagnoses corresponded closely to the DSM-III-R/IV criteria for panic disorder (see Clinical Studies).
Panic disorder (DSM-IV) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart, or accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or abdominal distress; (8) feeling dizzy, unsteady, lightheaded, or faint; (9) derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; (11) fear of dying; (12) paresthesias (numbness or tingling sensations); (13) chills or hot flushes.
- XANAX is not intended for recreational use. There may be serious risks if XANAX is taken by someone for whom it is not prescribed.
- Beware of counterfeit or fake XANAX. Counterfeits are illegal and potentially harmful. It’s hard to tell where or how they were made—or even what’s inside them. Learn more.
As with most medications, this product should be stored at room temperature. Store it in a secure location where it will not be exposed to excessive heat, moisture or direct sunlight. Make sure that any leftover portion is disposed of safely. This drug is occasionally sought out by teenagers for non-medical purposes. Please store in a safe place.
When it should not be used:
Do not take XANAX if you:
are allergic to the group of medicines known as
benzodiazepines (examples: clonazepam, chlordiazepoxide,
diazepam, or flurazepam).
are allergic to XANAX or any of the ingredients listed in the
section “What the nonmedicinal ingredients are”.
have acute narrow-angle glaucoma, a condition associated with
increased pressure in the eye that may cause loss of sight.
have myasthenia gravis, a chronic disease characterized by
the weakness of the skeletal muscles.
have a liver condition.
have lung disease or breathing problems.
have a sleep disorder that causes pauses in breathing or shallow
breathing while sleeping (sleep apnea).
are taking ketoconazole (e.g., Nizoral) or itraconazole (e.g.,
Sporanox), medicines used to treat fungal infections.
XANAX should not be used in patients under 18 years of age.
Warnings and precautions for use
This medicine contains lactose. Its use is not recommended in patients with galactose intolerance, lapp lactase deficiency or glucose or galactose malabsorption syndrome (rare hereditary diseases).
The anxiolytic effect of benzodiazepines and related drugs may gradually decrease despite the use of the same dose if administered for several weeks.
Any treatment with benzodiazepines and related drugs, and more particularly in the event of prolonged use, can lead to a state of physical and psychological dependence.
Various factors seem to favor the occurrence of addiction:
- duration of treatment,
- history of other drug dependencies or not, including alcoholism.
Drug dependence can occur at therapeutic doses and / or in patients without an individualized risk factor.
In the case of physical dependence, abrupt cessation of treatment may lead to withdrawal symptoms. These symptoms may be: insomnia, headache, myalgia, severe anxiety, nervous tension, impatience, confusion, irritability. In severe cases, the following symptoms may occur: derealization, depersonalization, hyperacusis, numbness and tingling of the extremities, hypersensitivity to light, noise and physical contact, hallucinations, seizures.
Withdrawal symptoms may appear within days of stopping treatment. For benzodiazepines with a short duration of action, and especially if they are given in high doses, symptoms may even appear in the interval between two doses.
The combination of several benzodiazepines, whatever the anxiolytic or hypnotic indication, may increase the risk of drug dependence.
The risks of withdrawal phenomenon being greater when the drug is abruptly stopped, it is recommended to gradually reduce the daily dose (see section Warnings and precautions for use “precautions for use, Duration and methods of stopping progressive treatment ”).
Cases of abuse have been reported.
This transient syndrome, the symptoms of which initially motivated treatment with benzodiazepines, can manifest itself exacerbated when treatment is stopped.
This syndrome can be accompanied by other reactions including mood changes, anxiety, and sleep disturbances and impatience.
The risk of rebound phenomenon being greater when the discontinuation of the drug is abrupt, it is recommended to gradually reduce the daily dose (see section Warnings and precautions for use “precautions for use, Duration and methods of stopping progressive treatment ”).
The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as diazepam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.